Dear colleagues, dear residents,
We are pleased to announce that our next webinar will take place on Friday, 25th October 2024 at
15:30-16:30 CEST.
Enrico Radaelli, Pennsylvania, USA, will present
The perils of humanization – a mouse perspective
Summary: Let’s deep dive into the world of humanized mouse models! Over the last decade, the use of chimeric humanized mouse models engrafted with a variety of tissues and cells of human origin has become one of the experimental paradigms most frequently used in translational research. This has been possible thanks to the establishment of genetically engineered mice with severely impaired innate and adaptive immune systems, such as NSG or NOG mice, offering a highly permissive recipient environment for the functional integration of the xenotransplanted human components.
However, in the permissive and unregulated environment of the immunocompromised recipient mouse, the cellular interactions are sometimes unpredictable. In this context, a series of unintended post-transplant disorders have been characterized in recent years. These disorders are clinically relevant for mouse recipients, limiting their usage, especially for longer-term studies, and represent potential experimental confounders for interpreting preclinical data.
If you would like to know more about these possible limitations, you’ll be in the right place! Or even if you want to get insights into translational research, this webinar is for you! Enrico has established a state-of-the-art comparative pathology program that supports the development, characterization, validation, and refinement of a variety of animal models of human diseases and it is worth to get his valuable perspective on the topic!
Please register in advance for this meeting under this link
The webinar will be presented via the professional version of Zoom. You should promptly receive an email with the access details (originating from <[email protected]>), please check your spam folder or get in touch with [email protected].
Best wishes
The ECVP-ESVP webinar team
The perils of humanization – a mouse perspective
Summary: Let’s deep dive into the world of humanized mouse models! Over the last decade, the use of chimeric humanized mouse models engrafted with a variety of tissues and cells of human origin has become one of the experimental paradigms most frequently used in translational research. This has been possible thanks to the establishment of genetically engineered mice with severely impaired innate and adaptive immune systems, such as NSG or NOG mice, offering a highly permissive recipient environment for the functional integration of the xenotransplanted human components.
However, in the permissive and unregulated environment of the immunocompromised recipient mouse, the cellular interactions are sometimes unpredictable. In this context, a series of unintended post-transplant disorders have been characterized in recent years. These disorders are clinically relevant for mouse recipients, limiting their usage, especially for longer-term studies, and represent potential experimental confounders for interpreting preclinical data.
If you would like to know more about these possible limitations, you’ll be in the right place! Or even if you want to get insights into translational research, this webinar is for you! Enrico has established a state-of-the-art comparative pathology program that supports the development, characterization, validation, and refinement of a variety of animal models of human diseases and it is worth to get his valuable perspective on the topic!
Please register in advance for this meeting under this link
The webinar will be presented via the professional version of Zoom. You should promptly receive an email with the access details (originating from <[email protected]>), please check your spam folder or get in touch with [email protected].
Best wishes
The ECVP-ESVP webinar team